Otto Krayer Professor of Systems Biology
Harvard Medical School
Boston, Massachusetts, United States
Peter Sorger is the Otto Krayer Professor of Systems Biology at Harvard Medical School and Head of the Harvard Program in Therapeutic Sciences. His research focuses on single cell measurement and modeling of oncogenic networks in cancer and inflammatory diseases, particularly the interplay between tumor-intrinsic mechanisms of invasion and metastasis and countervailing immune surveillance. This is performed in human cohorts and mouse models to elucidate molecular programs controlling cancer progression and response to therapeutic drugs applied individually and in combination. His group is currently developing experimental and computational methods for high-plex single-cell analysis of human tumors and tissues in 2D and 3D. In a research setting, 50-100 plex imaging can be performed on conventional FFPE histological specimens at sufficient resolution to visualize individual drug targets and signaling complexes (PD1-PDL1 for example) across enough markers to deeply phenotype the constituents of the tissue microenvironment, including all major immune subtypes. In a translational setting, efficient lower-plex methods integrated with hematoxylin and eosin-based histology and machine learning/AI modeling enables creation of a new generation of image-based molecular diagnostics. The Sorger lab aims to develop these into companion biomarkers and prognostic tests able to guide clinical trials and more fully realize the promise of precision medicine.
Human Tumor Atlas Network: Mapping Tumor Transitions at Molecular Resolution
Friday, November 22, 2024
3:45 PM – 4:45 PM PST