High Throughput Genomic Profiling of Solid Tumor FFPE Specimens with Fully Automated Extraction

Comprehensive Genomic Profiling (CGP) enables targeted therapy in oncology by identifying actionable mutations in solid tumors. Formalin-fixed paraffin-embedded (FFPE) tissues are challenging for high-quality nucleic acid extraction, crucial for sequencing. We present the Sonication STAR, an automated solution developed by Hamilton, Covaris, and Labcorp, enhancing FFPE sample processing for CGP. This method reduces 'quantity not sufficient' (QNS) samples, improves sequencing performance, and increases fully reported tumor profiles by 16%, offering cost savings, efficiency, and reduced re-extractions in CGP workflows."