Clinical sequencing applications require solutions that maximize the information output from samples where template mass and quality are limited, such as cell free DNA and FFPE material. Accessing this information requires multiple enzymatic manipulations that are inefficient and can corrupt data. Watchmaker has paired novel enzyme engineering with multidimensional reaction optimization to develop DNA and RNA NGS library preparation solutions that better maintain data integrity - minimizing bias and improving sequence accuracy to ultimately increase sensitivity. Join us to learn about these advances, as well as our current development work in the space of DNA methylation, where there is large scope for improvement on DNA recovery, data quality, and ease of workflow.