This workshop will explore the integration of chromosomal microarray and hotspot mutation analysis in solid tumor analysis. This approach enables accurate diagnosis and prognosis by identifying copy number abnormalities, loss of heterozygosity, and specific mutations. Key markers such as 1p/19q co-deletion for oligodendroglioma, 1p/16q loss of heterozygosity for Wilms' tumors, and BRAF fusion/rearrangement and BRAF V600 mutation for pediatric low-grade gliomas are highlighted. Real cases will be showcased, where this integration has provided essential results, enhancing the understanding and management of solid tumors.