Associate Professor Washington University St. Louis, Missouri, United States
Description: This presentation will describe approaches taken and lessons learned in creating bioinformatics tools for molecular pathology applications. Examples will be drawn from two examples: CIViCdb (https://civicdb.org/) a resource for somatic variant interpretation and pVACtools (https://pvactools.org/) a resource for personalized neoantigen vaccine design.
Learning Objectives: 1. Best practices for creating and updating a bioinformatics resource that will be used in a translational setting. 2. The current state and future directions of open resources for establishing the clinical significance of somatic variants. 3. Strategies to achieve robust results and rapid turnaround time for bioinformatics pipelines that support neoantigen targeting clinical trials.
