Chairman, Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center New York, New York, United States
Description: B-cell lymphomas comprise a heterogeneous group of biologically and clinically distinct neoplasms, many of which arise from mature germinal center B-cells. Over the last decade, studies have shown that alterations in oncogenes and tumor suppressor genes involved in germinal center biology play a critical role in B-cell lymphoma pathogenesis. In this talk, we will review recent discoveries in the molecular mechanisms driving the development and progression of B-cell lymphoma, including the role of mutations targeting the non-coding genome, with a focus on how these findings can be translated into improved diagnosis and treatment of lymphoma patients.
Learning Objectives: 1. Understand the genetic underpinnings of the initiation and progression of B-cell lymphomas. 2. Evaluate how recent discoveries in B-cell lymphoma pathogenesis can be exploited for the development of novel biomarkers and rational treatment options.
